La natura del legame chimico L'importanza biologica dei legami a idrogeno
"because of its small bond energy and the small activation energy involved in
its formation and rupture, the hydrogen bond is especially suited to play a part in
reactions occurring at normal temperatures. [It] restrains proteins to their native
configurations and I believe that as the methods of structural chemistry are further
applied to physiological problems it will be found that the significance of the hydrogen
bond for physiology is greater than that of any other single structural feature".
Il volume ebbe origine dalle Baker Lectures tenute alla Cornell University in 1936,
anno di pubblicazione di: A. E. Mirsky, L. Pauling , On the structure of native,
denatured, and coagulated proteins. Proc. Natl. Acad.Sci. USA,22, 439-447
- a remarkable prophecy made long before anything was known about protein structure.